The Sites of Hemoglobin Catabolism

Maximal erythrocyte and hemoglobin catabolism.

A series of experiments were performed on anesthetized dogs in which varying quantities of normal canine erythrocytes damaged by incubation with N-ethylmaleimide were injected into the circulation. Cell sequestration and catabolism of hemoglobin to carbon monoxide remained normal after injections that contained from 0.058 to 0.154 g of hemoglobin per kg of body weight. After administration of l...

Hemoglobin catabolism. II. The protection of hemoglobin from oxidative breakdown in the intact erythrocyte.

This protective system has a lasting effect only when the product of the reaction, GSSG, is continuously reduced to GSH. The work of previous investigators has shown that erythrocytes have an effective system for reducing GSSG (5-8). The TPN-linked reactions of the phosphogluconate pathway, in conjunction with glutathione reductase, maintain erythrocyte glutathione in the reduced state. In the ...

Inducible heme oxygenase in the kidney: a model for the homeostatic control of hemoglobin catabolism.

We have recently identified and characterized NADPH-dependent microsomal heme oxygenase as the major enzymatic mechanism for the conversion of hemoglobin-heme to bilirubin-IXalpha in vivo. Enzyme activity is highest in tissues normally involved in red cell breakdown, that is, spleen, liver, and bone marrow, but it usually is negligible in the kidney. However, renal heme oxygenase activity may b...

Hemoglobin and erythrocyte catabolism in rat liver: the separate roles of parenchymal and sinusoidal cells.

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...